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. Author manuscript; available in PMC: 2013 Oct 10.
Published in final edited form as: J Med Chem. 2011 May 6;54(11):3926–3934. doi: 10.1021/jm2002487

Scheme 1a.

Scheme 1a

aReagents: a) MOMCl, Hunig’s base, CH2Cl2; b) PhN(SO2CF3)2, KHMDS, THF, –78 °C; c) NaCN, CuI, Pd(PPh3)4, MeCN; d) DIBALH, toluene, CH2Cl2, –78 °C; e) PCC, CH2Cl2, f) EtOH, 6 N HCl; g) H2 (60 psi), Lindlar’s catalyst (5%), EtOAc.