Table 2.

Modulation of Rat α₁β₂γ_2L GABA_A Receptor Function by Steroids 1, 2 and Structural Analogues.

Compound	oocyte electrophysiologya
	0.1 µM	1 µM	10 µM	(gating) 10 µM
1b	2.91 ± 0.57	4.70 ± 1.11	19.64 ± 4.04	0.11 ± 0.02
2b	0.94 ± 0.04	0.97 ± 0.05	1.87 ± 0.14	0.08 ± 0.07
3b	1.12 ± 0.03	4.59 ± 0.42	21.14 ± 2.14	0.14 ± 0.03
4b	1.49 ± 0.44	4.07 ± 1.09	23.75 ± 3.61	0.21 ± 0.04
5a	0.77 ± 0.06	1.57 ± 0.15	10.78 ± 0.64	0.02 ± 0.01
5b	0.87 ± 0.02	1.44 ± 0.02	8.22 ± 0.14	0.04 ± 0.01
5c	0.91 ± 0.03	1.13 ± 0.08	4.67 ± 0.14	0.01 ± 0.01
6a	1.17 ± 0.04	5.06 ± 0.6	21.51 ± 7.07	0.17 ± 0.00
6b	0.79 ± 0.05	0.77 ± 0.04	1.82 ± 0.21	0.02 ± 0.01
6c	0.90 ± 0.05	1.52 ± 0.24	5.02 ± 0.62	0.04 ± 0.01
6d	0.90 ± 0.01	0.86 ± 0.04	1.53 ± 0.02	0.05 ± 0.02

^aThe GABA concentration used for the control response was 2 µM. Each compound was evaluated on at least four different oocytes at the concentrations indicated, and the results reported are the ratio of currents measured in the presence/absence of added compound. Gating represents direct current gated by 10 µM compound in the absence of GABA, and this current is reported as the ratio of compound only current/2 µM GABA current. Error limits are calculated as standard error of the mean (N ≥ 4). Methods were as reported previously. ²⁵

^bThese values are from the literature.²¹