Table 3.

Effects of Steroids 1, 2 and Structural Analogues on Tadpole Righting and Swimming Reflexes^a

Compound	Tadpole LRR EC50 (µM)	Tadpole LRR nHill	Tadpole LSR EC50 (µM)	Tadpole LSR nHill
1b	1.12 ± 0.14	−3.38 ± 2.28	5.48 ± 0.11	−33 ± 0c
2b	> 10	–	Noned	–
3b	0.72 ± 0.11	−1.49 ± 0.26	5.48 ± 0.12	−33 ± 0
4b	1.04 ± 0.14	−1.77 ± 0.38	5.48 ± 0.12	−33 ± 0
5a	3.22 ± 0.03	−16 ± 1.8	None	–
5b	3.98 ± 2.43	−2.76 ± 3.73	None	–
5c	3.58 ± 1.59	−3.21 ± 5.34	None	–
6a	1.44 ± 0.20	−2.84 ± 0.77	5.48 ± 0.20	−33 ± 0
6b	9.15 ± 5.37	−1.70 ± 1.15	17.3 ± 0.17	−36 ± 0
6c	2.71 ± 0.26	−2.47 ± 0.64	5.48 ± 0.20	−33 ± 0
6d	2.09 ± 0.12	−2.42 ± 0.24	> 10	–

^aThe methods are as reported previously. ²⁵ Error limits are calculated as standard error of the mean (N = 10 or more animals at each of five or more different concentrations).

^bThese values are from the literature.²¹

^cLSR typically has a very steep dose–response curve and the n_Hill values reflect the fact that at 3 µM (10 µM for compound 6b) all or nearly all animals had a swimming response and at 10 µM (30 µM for compound 6b) the animals did not.

^dNone indicated that all animals had a swimming response at 10 µM of the test compound.