Table 1.
Baseline characteristics of the study cohorts.
| Characteristics | Neonates with acquisition of infections with ESBL-producing organisms (n = 8) |
Neonates with acquisition of infections with non-ESBL-producing organisms (n = 39) |
|---|---|---|
| Median age in days at onset of sepsis (IQR) | 1 (1–7) | 3 (3–9) |
| Mean gestational age in weeks (SD) | 29 (3.2) | 37 (4.2) |
| Gender | ||
| Male (%) | 7 (88) | 29 (75) |
| Female (%) | 1 (12) | 10 (25) |
| Birthweight (%) | ||
| <1000 g | 3 (38) | 2 (5) |
| 1000–1499 g | 3 (38) | 5 (13) |
| 1500–2499 g | 2 (25) | 17 (44) |
| ≥2500 g | 0 (0) | 15 (39) |
| Preterm delivery (%) | 7 (88) | 13 (33) |
| Place of birth (%) | ||
| Inborn | 1 (12) | 2 (5) |
| Outborn | 7 (88) | 37 (95) |
| Hospital | 8 (100) | 30 (77) |
| Mode of delivery (%) | ||
| Vaginal delivery | 4 (50) | 26 (67) |
| Cesarean | 3 (38) | 12 (30) |
| Assisted delivery | 0 (0) | 1 (3) |
| Breech | 1 (25) | 0 (0) |
| Meconium stained amniotic fluid (%) | 1 (25) | 14 (36) |
| Risk factors for sepsis (%) | 3 (38%) | 14 (36) |
| Clinical signs of sepsis (%) | 5 (63) | 30 (77) |
| Positive sepsis screen (%) | 3 (38) | 19 (49) |
| Early onset sepsis (%) | 5 (63) | 23 (59) |
| Late onset sepsis (%) | 3 (38) | 16 (41) |
| Median days of hospital stay (IQR) | 61 (39–91) | 19 (11–21) |
| Median days of level 3 stay (IQR) | 54 (35–77) | 11 (7–22) |
| Median days of level 2 stay (IQR) | 8 (4–11) | 6 (2–8) |
| Outcome (%) | ||
| Expired | 2 (25) | 6 (15) |
ESBL: extended-spectrum beta-lactamase; IQR: interquartile range; SD: standard deviation.