Table 5.

Studies of oral dosage levels of probiotics in healthy volunteers and patients.

Organism(s)	Subjects	Dose levels (CFU/mL/day)	Response/outcomes	Reference
Lactobacillus paracasei subsp. paracasei (CRL-431)   L. acidophilus	Children and adults with diarrhea	107-108	Three 15 day trial periods; reduction in incidence of intestinal disorders	[25]
Lactobacillus GG	Healthy volunteers	108–1010	1-week trial; effective gut colonization	[26]
Bifidobacterium lactis BB-12  Lactobacillus GG	Children with atopic eczema	108-109	2-month trial; controlled allergic reactions	[27]
B. longum SBT2928	Healthy volunteers	1011	40-day trial; survival in the gut	[28]
Lactobacillus GG	Children with acute infectious diarrhea	109	Prophylactic; reduction in duration of diarrhea	[29]
L. casei subsp. rhamnosus Lcr35	Healthy volunteers	108–1012	1-week study; successful colonization of gut	[30]
L. reuteri ATCC 55730	Healthy volunteers	108	28-day trial; gut colonization; immune modulation	[31]
B. animalis subsp. lactis BB-12  Streptococcus thermophilus	Children with rotavirus diarrhea	108	Reduction in incidence of acute diarrhea and rotavirus shedding	[32]
B. lactis strain BB12	Healthy breastfed infants	106	Prophylactic against acute diarrhea	[33]
B. animalis subsp. lactis BB-12  L. reuteri ATCC 55730	Children with acute diarrhea	107	12-week trial; fewer and shorter episodes of diarrhea	[34]
L. delbrueckii subsp. bulgaricus  S. thermophilus	Healthy volunteers	107–109  (L. delbrueckii)   108–1010  (S. thermophilus)	12-day trial; effective gut colonization	[35]
B. animalis subsp. lactis BB-12  L. paracasei subsp. paracasei CRL-431	Healthy volunteers	108–1011	7-week study; fecal recovery increases with increase in dose	[36]
L. reuteri DSM 17938  L. rhamnosus GG	Healthy volunteers	109	3-week trial; increase in fecal recovery of viable lactobacilli	[37]
Pediococcus acidilactici MTCC 5101	Healthy human volunteers	108–1010	4-week trial; colonization and fecal recovery increases with time	Present study