Fig. 1. Schematic representation of the common structural andfunctional domains of ERα and ERβ. The cDNA coding for ER iscomposed of 8 exons. The functional domains of the receptors areindicated (A-F), as are the regions responsible for transcriptional activation, DNA binding, ligand binding, and heat shock protein (hsp) 90 binding. The percentage of amino acid homology betweenregions A through F in ERα and ERβ is indicated by the numberswritten on the structure of ERβ. Two transcriptional activation domains, activation function (AF) domains are present in the A/B and E region of the ERs.
