Fig. 5. Effects of inhibitors for HO-1 and SIRT1 on RSV-mediated cytoprotection. HT22 cells and the cells transiently transfected with either HO-1 siRNA or SIRT1 siRNA were pretreated with 10 μM RSV for 12 h, and then stimulated with 2 mM Glu for 24 h in the presence or absence of 20 μM SnPP, 5 μM sirtinol or 10 mM nicotinamide. MTT assay for cell viability was performed as described under Materials and Methods. Data are expressed as means ± SE from 3 and 4 experiments. *p<0.05.
