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. 2013 Jul 24;41(18):8788–8801. doi: 10.1093/nar/gkt594

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Effects of longer abasic duplex RNAs (22 mers) on expression of HTT. Duplex RNAs were tested in HD patient-derived fibroblast cells (GM04281, CAG 69/17). Averaged dose–response curves of RNA duplexes (A) AB18(Y33), (B) AB19(Y33), (C) AB20(Y16) and (D) AB21(Y16) containing three abasic substitutions.