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. 2013 Jul 24;41(18):8788–8801. doi: 10.1093/nar/gkt594

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Abasic duplex RNAs selectively inhibit mutant ataxin-3 expression. Duplex RNAs were tested in SCA3 patient-derived fibroblasts (GM06151, CAG 74/24). (A) Effects of abasic duplex RNAs on ATX-3 expression when transfected at 25 nM. Averaged western blot dose curves of duplex RNAs (B) AB4, (C) AB8, (D) AB18 and (E) AB19 were tested at increased concentrations. Dose curves are data from three independent experiments.