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. 2013 Jul 18;41(18):8434–8443. doi: 10.1093/nar/gkt618

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Physico-chemical origins of the mRNA/protein relationship. (A) Correlation coefficients (R and <R> with standard deviations) between PYR or PUR average codon content (‘Codon content’) and respective mRNA profiles (‘Profiles’) calculated for G- (blue), PUR- (red) and PYR- (green) binding preferences of amino acids, which were obtained using different amino acid neighbor statistics (1+, 2+ or 2). (B) A model of physico-chemical complementarity between proteins and cognate mRNAs. Preferential interactions of amino acids with PYR or PUR define their codon content in the genetic table and facilitate complementary interactions between PYR/PUR-rich mRNA regions and PYR/PUR preferring regions in proteins. The opposite behavior of adenines and guanines adds an additional layer of complexity in the case of PURs as signified by dashed arrows in the model. Note: polymer sizes not drawn to scale.