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. 2013 Jul 17;41(18):8475–8488. doi: 10.1093/nar/gkt623

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Frequency of conversions in Δsir1 cells. Δsir1, Δcac1 and wild-type cells harboring URA3 at the VIIL telomere and Δsir1, Δdot1 and wild-type cells harboring hmr-a1Δ::URA3 were selected on SC-ura and SC/FOA plates, grown in YPD medium for 20 generations, and analyzed as in Figure 4A. (A) Analysis of cells with URA3-tel. (B) Analysis of cells with hmr-a1Δ::URA3. (C) Best fit analysis of the conversion rates in Δsir1 hmr-a1Δ::URA3 cells. Cells were selected on SC/FOA (large gray squares) and SC-ura plates (large black squares) and transferred to YPD medium. Aliquots were taken out at known generation numbers and the percentage FOA^R cells were measured and plotted. Best fit algorithm (small diamonds) produced values of C_S→A = 5.66% and C_A→S = 0.17%.