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. 2013 Jul 25;41(18):8515–8525. doi: 10.1093/nar/gkt624

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Pin1 inhibition impairs GR transactivation. A549 cells were transfected with control or Pin1 siRNA, incubated for 48 h and then stimulated with 1 or 100 nM DEX for 2 h. GC-responsive genes were measured by qPCR (A) IP6K3, (B) GILZ, (C) hIAP, (D) IGFBP1, (E) FKBP5. (F) Pin1 gene expression was also determined to demonstrate the effect of the siRNA. Graphs show mean (±SD) fold change in gene expression compared with controls (RQ). Statistical significance was determined using a one-way ANOVA with a Bonferroni post-hoc test (P < 0.05*) to determine the effect of Pin1 (n = 7 for GILZ and Pin1, all other genes, n = 3).