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. 2013 Jul 19;41(18):8452–8463. doi: 10.1093/nar/gkt631

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Curation approach. (a) Protocol: based on a set of selected reviews, we defined the set of diauxic shift TGs. Each gene was queried for regulatory information in SGD, YEASTRACT and Herrgard et al. (26). The GRN was compiled from information directly retrieved from the resources and from the curation of all extracted references. The information collected in each step of our approach is detailed in (b). Slots on the x-axis from left to right: (1) Number of diauxic shift TGs for which regulatory information could be annotated; (2)–(6) Number of regulations with (2) either Signal or TF annotated; (3) Signal and TF; (4) regulation type: activation or inhibition; (5) effect strength: weak, medium, strong; (6) High confidence, see ‘Materials and Methods’ section; (7) Number of articles in which regulations could be annotated.