Table 1.

Genotoxin inducible DNA repair genes

Gene	Repair mechanism	Function	Inducing genotoxic agens	Transcription-factor	Reference
apex1	BER	Endonuclease	H2O2, ionizing radiation	AP-1	(8–10)
ddb1	NER	Damage recognition	ionizing radiation	?	(11)
ddb2	NER	Damage recognition	UV-C, adriamycin, cisplatin, BPDE, ACNU, BCNU, ionizing radiation, fotemustine	p53, BRCA1, p63	(12–20)
ercc1	NER	Co-Factor of XPF	ionizing radiation, arsenic com., B[a]P	AP-1	(21–26)
fen1	BER	Flap-Endonuclease	UV-C, MMS	p53	(27,28)
karp1	NHEJ	Ku-Binding	ionizing radiation, UV-C, etoposide, MMS	p53	(29)
lig1	BER	Ligase	UV-C	?	(30)
mgmt	Damage reversal	Alkyltransferase	ionizing radiation,UV-C, MMS	p53, AP-1,NF-κB	(31–37)
mpg	BER	Glycosylase	UV-C, TPA, EMS	Sp1, AP-2	(38,39)
mlh1	MMR	ATPase	cisplatin	p53	(40)
msh2	MMR	Damage recognition	UV-B, TPA	p53, AP-1	(41,42)
neil1	BER	Glycosylase	ROS	AP-1	(43)
ogg1	BER	Glycosylase	MMS, ionizing radiation	NF-YA	(44,45)
pcna	several	Replication clamp	ionizing radiation, UV-C	p53, AP-1	(46–49)
pms2	MMR	Endonuclease	cisplatin	p53	(40)
polI	TLS	Polymerase	UV-C, MNNG	Sp1	(50,51)
polβ	BER	Polymerase	MNNG, MMS	TFEIF, CREB-1, ATF-1	(52–56)
polH	TLS	Polymerase	ionizing radiation, CPT	p53	(57)
polK	TLS	Polymerase	BPDE	HSF1	(58)
rev3	TLS	Polymerase	MNNG	?	(59,60)
trex1	several?	Exonuclease	UV-C, BPDE, CPT, ACNU, TPT, fotemustine	AP-1	(61–63)
xrcc1	BER, SSBR	Scaffold protein	ionizing radiation, MMS	E2F1	(21,22,64)
xpc	NER	Damage recognition	UV-C, γ-ray , MMS, B[a]P, ACNU, BCNU, fotemustine	p53, BRCA1	(14,15,19,20,65–69)
xpf	NER	Endonuclease	UV-C, B[a]P, ionizing radiation	AP-1	(11,70–72)
xpg	NER	Endonuclease	UV-C, B[a]P	AP-1, E2F1	(70–72)