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. 2013 Jul 26;41(18):8537–8545. doi: 10.1093/nar/gkt642

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Nucleosomes enhance SIRT6 deacetylase activity. (A) Time course analysis of a recombinant bacterial–expressed SIRT6-Flag deacetylation of H3K9Ac and H3K14Ac as part of histone octamers (left) or nucleosomes (right). (B) Kinetics of SIRT6-Flag deacetylation of H3K9Ac. (C–G) Kinetics of SIRT6-Flag deacetylation of H3K56Ac, H4K5Ac, H4K8Ac, H4K12Ac and H4K16Ac. (H) Global acetylation of H3K9, H3K14, H3K56, H4K5, H4K8, H4K12 and H4K16 in HeLa cells following SIRT6 knockdown.