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. Author manuscript; available in PMC: 2013 Oct 10.
Published in final edited form as: Biol Blood Marrow Transplant. 2013 Mar 22;19(6):925–933. doi: 10.1016/j.bbmt.2013.03.010

Figure 4.

Figure 4

Changes in serum cytokines and chemokines. (A) Infusions of aATC-induced cytokines and chemokines. aATC infusions enhanced cytokines IL-2R and IL-12 and IFN-γ–induced chemokines CXCL10 (IP-10) and CXCL9 (MIG) in 4 patients at indicated time points (*P < .05). (B) Top: sequential mean (±SD) fold increase in serum levels for T cell proliferation inducing cytokines IL-2, IL-7, and IL-15 (left) and serum chemokines MIP-1β and MIP-1α and IFN-γ–induced chemokines CXCL10 (IP-10) and CXCL9 (MIG). Bottom: sequential serum levels for IFN-γ and IL-12. Serum samples were analyzed in 3 patients after the second infusion at the designated times. (C) Transfer and reconstitution ofIgG and anti-TT. The results for individual patients are presented. Total IgG was tested before and at 3 months after SCT to determine the levels of IgG transferred in the stem cell product aATC infusions did not affect total IgG levels in the serum. (D) Anti-TT before and at 3 months after SCT were analyzed to determine whether the levels of specific anti-TT transferred in the stem cell product.