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. Author manuscript; available in PMC: 2014 Sep 3.
Published in final edited form as: Cell Metab. 2013 Sep 3;18(3):416–430. doi: 10.1016/j.cmet.2013.07.013

Figure 1. BRASTO mice show the extension of both median and maximum life span and delay the age-associated mortality rate and the incidence of cancer-dependent death.

Figure 1

(A) Kaplan-Meier curves of BRASTO (Tg) and wild-type control (WT) mice in females (top left), males (top right) and combined sex (bottom left). P values shown were calculated by log-rank test. (B) Changes in age-associated mortality rate by plotting linear hazard rate in females, males and combined sex. P values for the differences of fitted slopes (not significant) and y-axis intercepts (shown in each panel) were calculated by ANCOVA between BRASTO and wild-type control mice. (C and D) Accumulating incidents of cancer-dependent deaths (C) and identified causes of death (D) in aged BRASTO and wild-type control mice. P value (top) for the difference of the two genotypes was calculated by log-rank test. P values for the differences of fitted slopes (not significant) and y-axis intercepts (bottom) were calculated by ANCOVA. See also Figure S1.