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. Author manuscript; available in PMC: 2014 Sep 3.
Published in final edited form as: Cell Metab. 2013 Sep 3;18(3):416–430. doi: 10.1016/j.cmet.2013.07.013

Figure 2. Aged BRASTO mice display higher physical activity, body temperature, oxygen consumption, and better quality of sleep compared to wild-type control mice.

Figure 2

(A) Wheel-running activity of BRASTO (Tg) and wild-type control (WT) mice at 20 months (left) and 4 months (right) of age, respectively. Activity counts per minute at each time point are shown as mean values ± S.E. (***p<0.001 by Wilcoxon matched-pairs singled-ranks test, n=10–12 mice for each genotype). (B and C) Rectal body temperature (B) and oxygen consumption (VO2) (C) at 20 months of age. Rectal body temperature and VO2 at each time point are shown as mean values ± S.E. [**p<0.01 by Student’s t-test (B); *p<0.05 by Wilcoxon matched-pairs singled-ranks test (C, 10pm to 5am), n=10–12 mice for each genotype]. (D and E) Levels of delta power in NREM sleep (D) and wake (E) at 20 months of age. Levels of delta power at each time point are shown as mean values ± S.E. (***p<0.001 by Wilcoxon matched-pairs singled-ranks test, n=5–6 mice for each genotype). Shaded area represents the dark time. See also Figure S2.