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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Allergy Clin Immunol. 2013 Aug 1;132(4):881–888.e11. doi: 10.1016/j.jaci.2013.06.008

FIG 4. Effect of diphtheria toxin-mediated basophil depletion on peanut-induced anaphylaxis in Mcpt8DTR mice.

FIG 4

PN-sensitized Mcpt8+/+ (n=10) and Mcpt8DTR/+ (n=10) mice were treated with DT 48 h before challenge with PN. (A) PN-induced hypothermia. (B–C) Representative flow cytometry plots (B) and percentage (C) of blood basophils (CD49b+; IgE+). (D) Numbers of MCs in the peritoneal lavage fluid. Data are mean ± SEM or mean + SEM; * ** or *** = P < 0.05, < 0.01 or < 0.001 vs. corresponding Mcpt8+/+ group; Crossbones symbol indicates death of one mouse.