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. Author manuscript; available in PMC: 2013 Oct 10.
Published in final edited form as: Nat Commun. 2012;3:1122. doi: 10.1038/ncomms2128

Figure 6. Integrin Surface Expression Correlates with ECM binding profiles.

Figure 6

(a) Flow cytometry of integrin surface expression in 393T5 (TMet) and 393M1 (M) cell lines. Integrin subunits that bind to metastasis-associated molecules show increased surface presentation in the metastatic line (α5, αv, α6, α3), while those that bind to primary tumor-associated molecules show decreased presentation (α1 and α2). (b) IHC for metastasis-associated integrins in mice bearing autochthonous tumors with spontaneous metastases to the liver and lymph nodes. Scale bars are 100µm.