Table 1.

Relevant miRNAs in oxidative stress response.

ROS source/pathology	miRNAs upregulated	Tissue/organ	Source	Target	Functions	References
H2O2	miR-200c miR-141 miR-200a miR-200b miR-429	endothelium, myoblasts	Human	ZEB1	apoptosis, senescence	[22]
H2O2	miR-200c miR-141 miR-200a miR-200b miR-429	ovarian adenocarcinomas	Human	p38α	ROS accumulation; improved response to chemotherapy	[25]
H2O2	miR-200c	primary hippocampal neurons	Mouse	Unknown	Unknown	[26]
chronic H2O2 treatment	miR-200c	trabecular meshwork cells	Human	Unknown	senescence	[27]
t-BHP	miR-200c miR-141	auditory cells	Mouse	Unknown	Unknown	[28]
Obesity	miR-200c miR-141	Heart	Rat	S6K1	compensatory/adaptive mechanisms	[29]
Diabetes	miR-200c miR-141	Heart	Mouse	Slc25a3	dysregulation ATP production; cell death	[30]
Diabetes	miR-200c miR-200b miR-429	VSMCs	Mouse	ZEB1	inflammation	[31]
NO	miR-200c miR-200a miR-200b miR-429	mES	Mouse	ZEB2	mesendoderm and cardiovascular differentiation	[32]
Hypoxia/ROS	miR-210	ASCs	Human	PTPN2	proliferation, migration	[33]
Hypoxia	miR-210	ECs, breast and colon cancer cells	Human	ISCU1/2	mitochondrial respiration	[34–36]
Hypoxia	miR-210	breast cancer cells	Human	TfR1	mitochondrial respiration; proliferation	[37]
Hypoxia	miR-210	H9c2 Cardiomyocytes	Mouse	FECH	heme biosynthesis; Iron homeostasis	[38]
Hypoxia	miR-210	colon, breast, esophageal cancer cells	Human	COX10	mitochondrial respiration; ROS production	[39]
Hypoxia	miR-210	lung cancer cells	Human	SDHD	mitochondrial respiration; proliferation	[40]
Hypoxia	miR-210	ovarian cancer cells	Human	NDUFA4	mitochondrial respiration	[41]
Diabetes	miR-125	VSMCs	Mouse	Suv39h1	inflammation	[42]
Obesity	miR-27	Adipose tissue	Mouse	PPARγ, C/EBPα	inflammation	[43]
H2O2	miR-21	VSMCs	Rat	PDCD4	apoptosis protection	[44]
Coronary artery disease	miR-21	APCs	Human	SOD-2 SPRY-1	ROS production; APC migratory defects	[45]
Atherosclerosis	miR-217	Atherosclerotic plaques	Human	SIRT-1	endothelial dysfunction	[46]
Myocardial infarction	miR-34	BMCs	Human	SIRT-1	apoptosis	[47]
Mitochondrial dysfunction	miR-23a/b	B lymphoma, prostate cancer cells	Human	Mitochondrial GLS	ROS production	[48]
Mitochondrial dysfunction	miR-15 family, miR-424	Cardiomyocytes	Rat	Arl2	ATP reduction	[49]
	downregulated:
Obesity	miR-155 miR-183 miR-872	Adipose tissue	Rat	HO-1	inflammation, oxidative damage, apoptosis	[50]
Hypoxic preconditioning	miR-199a	Cardiomyocytes	Rat	SIRT-1	apoptosis protection	[51]
H2O2	miR-23a/b	Retinal pigment epithelial cells	Human	Fas	apoptosis	[52]