Table 2.
lncRNAs in adaptive immunity.
| lncRNA | Genomic coordinates | Lenght | Expression | Characteristics | Proposed function | References | |
|---|---|---|---|---|---|---|---|
| has lncRNAs | Tmevpg1 (NeST) | chr12: 68, 383, 225-68, 415, 107 | 32 kb | Activated CD8+ T cells CD4+ Th1 and Th17 cells |
Its expression is regulated by Tbet and STAT4 | Epigenetic control of Ifnγ locus | [103–105] |
| NRON | chr9: 129, 170, 054-129, 172, 783 | 2.7 kb | CD4+ and CD8+ T cells | Sequence omology conserved back to chicken | Modulator of NFAT nuclear trafficking | [101] | |
| mmu lncRNAs | AK009498 | chr1: 58, 711, 508-58, 713, 886 | 710 bp | CD4+ and CD8+ effector and memory cells | Overlaps flip transcription start site | Potential negative regulator of Flip | [14] |
| Lef1as (AK029296) | chr3: 131, 109, 026-131, 112, 090 | 3 kb | naive CD8+ T cells | Located antisense to Lef1 mRNA | Possible role in suppressionLef1 | [14] | |
| AK053349 | chr14: 115, 044, 497-115, 046, 726 | 2.2 kb | effector CD8+ T cells | Partially overlaps miR-17-92 cluster | unknown | [14] | |
| AK020764 | chr11: 87, 755, 577-87, 757, 267 | 1.6 kb | effector CD8+ T cells | It hosts in its first intron miR-142 | Possible functional link with miR-142 | [14] |