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Bis-ester protected AI-2 analogs and proposed model of action in enteric bacteria. (a) Sructures of bis-ester protected AI-2 analogs; (b) Proposed pro-drug activation and processing of AI-2 in enteric bacteria. Ester protected AI-2 analogs diffuse into the bacterial cell. The analogs are cleaved by esterase and are subsequently phosphorylated by LsrK. (Taken from [68] with permission. Copyright 2012, MDPI).
