Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Sep 3;14(9):18041–18055. doi: 10.3390/ijms140918041

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

The proposed mechanisms for ziyuglycoside II induced cell cycle arrest and apoptosis in MDA-MB-435 cells. Ziyuglycoside II increased the accumulation of ROS, which resulted in the up-regulated expression of p53, p21 and Bax but down regulated expression of Bcl-2 in MDA-MB-435 cells. Consequently, the mitochondrial membrane potential (MMP) was reduced and then accelerated the release of cytochrome c into cytoplasm leading to the apoptosis of MDA-MB-435 cells via the caspase-3 and caspase-9 dependent pathway.