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The molecular mechanisms of current antiepileptic drugs.
| Mechanism | Drug |
|---|---|
| Blockage of voltage-gated sodium channels | Phenytoin |
| Fosphenytoin | |
| Carbamazepine | |
| Valproate | |
| Lamotrigine | |
| Oxcarbazepine | |
|
| |
| Enhancement of GABA inhibition | Phenobarbital |
| Primidone | |
| Diazepam | |
| Lorazepam | |
| Clonazepam | |
| Tiagabine | |
| Valproate | |
|
| |
| Blockage of low-threshold (T-type) Ca2+ channels | Ethosuximide |
| Gabapentin | |
| Valproate | |
|
| |
| Reduction of glutamate excitation | Felbamate |
| Gabapentin | |
| Parampanel | |
