Table 2.

Classification of animal models of SE.

Classification	Model	References
Electrical models	Perforant pathway stimulation	[28,41–43]
	Self-sustaining stimulation	[44–46]
Chemical models	Kainic acid	[25,31,47–52]
	Pilocarpine	[26,53–58]
	Lithium-pilocarpine	[26,59,60]
	Organophosphates	[37,61–63]
	Flurothyl	[64–67]
	Cobalt-homocysteine thiolactone	[68]
Thermal models	Hyperthermia or febrile seizures	[69–74]
In vitro models	Low magnesium in brain slices	[75–77]
	High potassium in brain slices	[78–80]
	4-Aminopyridine in brain slices	[81–84]
	Organotypic slice cultures	[85–89]
Refractory models	Lithium-pilocarpine	[37,90,91]
	Kainic acid	[25,31,92–94]
	DFP	[37,62,95,96]