Table 3.
Feature | Kainic acid | Pilocarpine | DFP | PPS | Hyperthermia |
---|---|---|---|---|---|
Technical feasibility | Simple | Simple | Complex | Tedious | Tedious |
Mortality rate | High | High | Medium | Low | Low |
Acute neuronal injury | Severe | Severe | Severe | Moderate | Minimal |
Diazepam response (early: <10-min) | Sensitive | Sensitive | Sensitive | Sensitive | Sensitive |
Diazepam response (late: >40-min) | Insensitive | Insensitive | Insensitive | Sensitive | Sensitive |
Neuroinflammation | Robust | Robust | Robust | Moderate | Moderate |
Chronic hyperexcitability | Severe | Severe | Severe | Severe | Moderate |
Neurodegeneration (>2 months post SE) | Severe | Severe | Severe | Moderate | Minimal |
Spontaneous seizures (>2 months post SE) | Severe | Severe | Severe | Moderate | Minimal |
Mossy fiber sprouting (>2 months post SE) | Severe | Severe | Severe | Moderate | Moderate |