Table 3.

General profiles of selected animal models of SE.

Feature	Kainic acid	Pilocarpine	DFP	PPS	Hyperthermia
Technical feasibility	Simple	Simple	Complex	Tedious	Tedious
Mortality rate	High	High	Medium	Low	Low
Acute neuronal injury	Severe	Severe	Severe	Moderate	Minimal
Diazepam response (early: <10-min)	Sensitive	Sensitive	Sensitive	Sensitive	Sensitive
Diazepam response (late: >40-min)	Insensitive	Insensitive	Insensitive	Sensitive	Sensitive
Neuroinflammation	Robust	Robust	Robust	Moderate	Moderate
Chronic hyperexcitability	Severe	Severe	Severe	Severe	Moderate
Neurodegeneration (>2 months post SE)	Severe	Severe	Severe	Moderate	Minimal
Spontaneous seizures (>2 months post SE)	Severe	Severe	Severe	Moderate	Minimal
Mossy fiber sprouting (>2 months post SE)	Severe	Severe	Severe	Moderate	Moderate