Table 3.
Examples of lncRNAs dysregulated in complex human diseases.
| LncRNA | Disease | References |
|---|---|---|
| aHIF | Multiple cancers | [61,62] |
| AK023948 | Papillary thyroid carcinoma | [63] |
| ANRIL | Coronary artery disease; Multiple cancers | [64–68] |
| ASFMR1 | Fragile X syndrome; Fragile X tremor ataxia syndrome | [69] |
| ATXN8OS | Spinocerebellar ataxia type 8 | [70] |
| BACE1-AS | Alzheimer’s disease | [71] |
| BC200 | Alzheimer’s disease; Multiple cancers | [72–74] |
| BIC | B-cell lymphoma | [75] |
| CUDR | Squamous carcinoma | [76] |
| DD3 | Prostate cancer | [77,78] |
| FMR4 | Fragile X syndrome; Fragile X tremor ataxia syndrome | [79] |
| GAS5 | Breast cancer | [80] |
| H19 | Multiple cancers | [81–85] |
| HOTAIR | Multiple cancers | [16,86] |
| HULC | Multiple cancers | [87,88] |
| Kcnq1ot1 | Colon cancer | [89] |
| Kras1p | Prostate cancer | [30] |
| Linc-p21 | Lung cancer | [43] |
| LOC285194 | Osteosarcoma | [90] |
| MALAT-1 | Multiple cancers | [91–93] |
| MEG3 | Multiple cancers | [94–97] |
| MIAT | Myocardial infarction | [98] |
| ncRAN | Neuroblastoma | [99,100] |
| NDM29 | Neuroblastoma | [101] |
| PCGEM1 | Prostate cancer | [102] |
| PRINS | Psoriasis | [103] |
| PRNCR1 | Prostate cancer | [104] |
| PTENP1 | Prostate cancer | [30] |
| RMRP | Leukemia and lymphoma | [105] |
| SAS-ZFAT | Autoimmune thyroid disease | [106] |
| SPRY4-IT1 | Melanoma | [107] |
| SRA-1 | Breast cancer | [108,109] |
| TERC | Multiple cancers | [110] |
| Ube3a-as | Angelman syndrome | [111,112] |
| uc.73A | Colon cancer | [32] |
| UCA1 | Bladder cancer | [113–115] |
| Zfas1 | Breast cancer | [116] |