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. 2013 Sep 17;14(9):19128–19145. doi: 10.3390/ijms140919128

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Metabolites modulate the morphology of apoSOD1 aggregates. TEM images of apoSOD1 with or without metabolites at a metabolite:protein ratio of 4, after incubation at pH 7.4 under agitation at 37 °C for 200 h. (A,B) Control, apoSOD1 with no added metabolite; (C) +lysine; (D) +erythronic acid; (E) +glyceric acid; (F) +glyceric acid, magnification of panel E; (G) +phthalate; (H) +arginine; (I) +fructose; (J) +ornithine; (K) +ornithine, magnification of panel J. See experimental section for further details.