Table 1.
Metabolites present in the cerebrospinal fluid (CSF) metabolome.
| Compound | Compound properties | CSF levels (μM) | Sporadic ALS | ||
|---|---|---|---|---|---|
|
| |||||
| Type | Physiological charge | Normal | Altered | ||
| l-Arginine | +1 | 15–25 | 6–21 | decreased | |
| l-Lysine | amino acid | +1 | 18–30 | 45 | decreased |
| l-Ornithine | +1 | 4–8 | 7–8 | unchanged | |
|
| |||||
| Glyceric acid | sugar acid | −1 | 34 | n.a. | decreased |
| Phthalate | exogenous | −2 | n.a. | n.a | unchanged |
|
| |||||
| Fructose | monosaccharide | 0 | 160–240 | n.a. | decreased |
| Erythronic Acid | −1 | 5 | n.a | unchanged | |
Normal and altered metabolite concentrations (approximated to the closest integer values) and predicted physical properties were extracted from the Human Metabolome Database Version 3.5 at http://www.hmdb.ca/ [42]. Information on relative variation of metabolites in sporadic ALS is taken from [14]. n.a., not available.