Table 3.
Histopathologic reports of patients with and without tumor recurrence
| Reports | Recurrence (n=128) | Nonrecurrence (n=119) | P-value |
|---|---|---|---|
| Histologic types | 0.465 | ||
| Adenocarcinoma | 83 (64.8) | 69 (58.0) | |
| Squamous cell carcinoma | 31 (24.2) | 37 (31.1) | |
| Others* | 14 (10.9) | 13 (10.9) | |
| Tumor grading | 0.544 | ||
| Well differentiated | 48 (37.5) | 34 (28.6) | |
| Moderately differentiated | 52 (40.6) | 55 (46.2) | |
| Poorly differentiated | 20 (15.6) | 19 (16.0) | |
| Undifferentiated | 3 (2.3) | 7 (5.9) | |
| Mucinous type of adenocarcinoma in situ | 3 (2.3) | 2 (1.7) | |
| Nonmucinous type of adenocarcinoma in situ | 2 (1.6) | 2 (1.7) | |
| Pathologic staging | 0.004 | ||
| IA | 12 (9.4) | 25 (21.0) | |
| IB | 22 (17.2) | 25 (21.0) | |
| IIA | 24 (18.8) | 21 (17.7) | |
| IIB | 15 (11.7) | 21 (17.7) | |
| IIIA | 53 (41.4) | 24 (20.2) | |
| IIIB | 2 (1.6) | 3 (2.5) | |
| Tumor diameter | 0.340 | ||
| ≤5 cm | 84 (65.6) | 82 (68.9) | |
| >5 cm | 44 (34.4) | 37 (31.1) | |
| Nodal involvement | <0.001 | ||
| Nodal Negative | 61 (47.7) | 83 (69.8) | |
| Nodal positive† | 67 (52.3) | 36 (30.3) | |
| Tumor necrosis | 55 (43.0) | 46 (38.7) | 0.288 |
| Visceral pleural invasion | 27 (21.1) | 21 (17.7) | 0.301 |
| Neural invasion | 7 (5.5) | 3 (2.5) | 0.198 |
| Intratumoral lymphatic invasion | 112 (87.5) | 95 (79.8) | 0.072 |
| Intratumoral blood vessel invasion | 63 (49.2) | 38 (31.9) | 0.004 |
| ERCC1 expression | 0.272 | ||
| Low expression | 77 (60.2) | 77 (64.7) | |
| High expression | 51 (39.8) | 42 (35.3) | |
| RRM1 expression | 0.375 | ||
| Low expression | 81 (63.3) | 72 (60.5) | |
| High expression | 47 (36.7) | 47 (39.5) |
Notes: Values are n (%).
*
Other cell types included adenocarcinoma in situ, large cell carcinoma, adenoid cystic carcinoma,lymphoepithelioma-like carcinoma, and adenosquamous cell carcinoma;
†
nodal positive refers to the presenting of malignant cells in any node level (1–14).
Abbreviations: n, number; ERCC1, excision repair cross-complementing group 1 gene; RRM1, ribonucleotide reductase M1 gene.