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. 2013 Oct 10;8(10):e75917. doi: 10.1371/journal.pone.0075917

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© 2013 Xu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Dietary triglycerides increase free fatty acids (FA) in circulation that are taken up by the liver and acutely activate the Pparγ2 gene that in turn induces the expression of the lipid droplet genes Fsp27 and Cidea and increases triglyceride storage. During perinatal development GCN2 in the developing brain senses lipid concentrations provided maternally and signals the liver to program Pparγ2 for future triglyceride storage levels. GCN2 programming of Pparγ2 will specifically dictate the future expression of FSP27 and CIDEA and hepatic triglyceride storage but not that of adipose tissue.