Table 2. Principal maternal outcomes by level of proteinuria adjusted for age and ethnicity with risk ratios in comparison with PE 300 group (proteinuria 300- 499 mg/24 hours).
| Preeclampsia | Preeclampsia | Chronic Hypertension | Gestational Hypertension | |
|---|---|---|---|---|
| 300-499 mg/day | ≥500 mg/day | |||
| N | 60 | 161 | 615 | 110 |
| Gestational age at diagnosis of preeclampsia, weeks | 35.2 (3.8) | 33.2 (4.1) | - | - |
| Severe gestational hypertension, N (%) | 16 (26.7%) | 58 (34.8%) | 36 (5.9%) | 11 (10.0%) |
| Diastolic blood pressure >110mmHg Risk ratio | 1.30 (0.82 to 2.09) | 0.22 (0.13 to 0.37)*** | 0.38 (0.19 to 0.76)** | |
| Maternal Intensive care unit admission, N (%) | 1 (1.7%) | 4 (2.5%) | 3 (0.5%) | 1 (0.9%) |
| Medication use after enrollment, N (%) | ||||
| Parenteral anti-hypertensive use | 2 (3.3%) | 13 (8.1%) | 8 (1.3%) | 3 (2.7%) |
| Magnesium sulfate use | 1 (1.7%) | 28 (17.4%) | 5 (0.8%) | 1 (0.9%) |
| Risk Ratio | 10.43 (1.45 to 75.01) * | |||
| Antenatal steroids | 17 (28.3%) | 64 (39.8%) | 41 (6.7%) | 6 (5.5%) |
| 0.24 (0.14 to 0.39)*** | 0.19 (0.08 to 0.46)*** | |||
| Laboratory Investigations | ||||
| N | 52 | 149 | 369 | 80 |
| Highest antenatal alanine aminotransferase (IU/L) (ALT) (Median, IQR) | 17(13.25 to 29.75) | 17 (11.5 to 26.5) | 16 (12 to 22) * | 15 (11 to 22) |
| Risk Ratio | 0.78 (0.63 to 0.96) | |||
| ALT >40IU/L , N(%) | 8 (15.4%) | 18 (12.1%) | 24 (6.5%) | 8 (10.0%) |
| N | 59 | 1160 | 452 | 99 |
| Lowest antenatal platelets (x109/L) (Median, IQR) | 210 (171 to 276) | 224.5 (176 to 264) | 241 (204 to 286)* | 254 (218 to 284) ** |
| Risk Ratio | 1.10 (1.02 to 1.20) | 1.15 (1.05 to 1.26) | ||
| Platelets <100 x109/L N(%) | 1 (1.7%) | 3 (1.9%) | 3 (0.7%) | 0 |
| N | 55 | 161 | 386 | 93 |
| Highest antenatal Creatinine (µmol/L) (Median, IQR) | 69 (62 to 77) | 75 (66 to 87) ** | 67 (60 to 74) | 68 (61 to 75) |
| Risk Ratio | 1.11 (1.04 to 1.19) | |||
| Creatinine >90µmol/l, N(%) | 4 (7.1%) | 30 (18.4%) | 13 (3.4%) | 7 (7.5%) |
Data are given as mean (standard deviation) or number (percentage) together with risk ratios and 95% confidence intervals (CI).
Risk ratio, p in comparison with preeclampsia with proteinuria of 300 - 499 mg/24 hours; *P≤0.05; **P≤0.01; ***P≤0.001