Table 1. Clinical characteristics of patients with PiB(-) and PiB(+) SVaD.
PiB(-) (n = 45) | PiB(+) (n = 23) | p | |
Demographics | |||
Age | 71.9±7.4 | 78.1±4.7 | <0.001 |
Gender, M:F | 21:24 | 06:17 | 0.101 |
Education | 8.3±4.8 | 9.1±5.5 | 0.523 |
Risk factors | |||
Hypertention | 36 (80%) | 18 (78.3%) | 1.000 |
Diabetes | 11 (24.4%) | 6 (26.1%) | 0.882 |
Hyperlipidemia | 20 (44.4%) | 6 (26.1%) | 0.141 |
Cognition | |||
MMSE | 21.4±4.7 | 18.7±4.9 | 0.036 |
CDR-SOB | 6.0±3.8 | 6.5±3.8 | 0.61 |
MRI markers | |||
WMH volume, ml | 41.9±15.6 | 45.5±22.9 | 0.447 |
Total lacune, n | 21.1±18.3 | 7.0±6.9 | <0.001 |
Intracranial volume | 1381.4±134.3 | 1390.4±155.1 | 0.804 |
APOE genotype | |||
APOE4 carriers | 9 (21.4%) | 10 (43.5%) | 0.062 |
Medication | |||
Antipsychotics | 1 (2.2%) | 2 (8.7%) | 0.219 |
Antidepressant | 5 (11.1%) | 2 (8.7%) | 0.756 |
Anxiolytics | 4 (8.9%) | 4 (17.4%) | 0.303 |
Abbreviations: PiB, Pittsburgh compound B; MMSE, Mini-Mental State Examination; CDR-SOB, clinical dementia rating sum of boxes; WMH, white matter hyperintensities; APOE4, Apolipoprotein E epsiolon 4.