Figure 5.

(A) Serum half-life of nanoparticles after tail vein injection of 10 mg Fe/kg of mouse body weight (open squares), where iron concentration was measured by spectrophotometry. Triangle represents serum iron concentration in noninjected control mice. The error bar is the standard deviation with four mice in each time point. (B) Biodistribution of PEO-b-PγMPS-coated IONPs in the major organs of BALB/c mice, including liver, spleen, kidney, lung, brain, and muscle. The data were recorded from the whole organ taken at indicated time points after tail vein injection and were determined by spectrophotometry. Each group contains four mice, and the error bar is the standard deviation.

Abbreviations: IONPs, iron oxide nanoparticles; PEO-b-PγMPS, poly(ethylene oxide)-block-poly(γ-methacryloxypropyltrimethoxysilane); h, hours.