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. 2013 Oct 10;8(10):e75716. doi: 10.1371/journal.pone.0075716

Figure 5. Adiponectin increases the responsiveness of OSN populations which react to different odorous compounds.

Figure 5

(A) Coronal section through ectoturbinate 2 of a mouse treated with buffer solution and exposed to 1-heptanal after Egr-1 in situ-hybridisation. The boxed area is shown in B. (B) High magnification of the epithelium shows numerous Egr1 positive cells. (C) High magnification of the same region as in B from a mouse treated with adiponectin and exposed to 1-heptanal. Numerous OSNs are Egr-1 positive. (D - E) High magnification showing an area on ectoturbinate 2 from a buffer-treated mouse (D) and an adiponectin-treated mouse (E) after exposure to 2,3-hexanedione. (F) Number [n] of Egr-1 positive cells on 50 consecutive sections through ectoturbinate 2 of control (white bars) and adiponectin-treated animals (black bars). Adiponectin increases the number of Egr-1 positive cells for both odorants. (1-heptanal: control: 442.6±80.7; adipo+: 668.2±24.4; P = 0.0003; 2,3-hexanedione: control: 390.3±145.7; adipo+: 637.8±193.2; P = 0.0311). All numbers in this figure are given as means ± SD. ***, extremely significant; *, significant. Scale bar: 0,2 mm in A; 50 µm in B-E.