Table 2.
Liver and kidney function in the four groups before and after treatment
| Groups | n | ALT (U/L) | AST (U/L) | BUN (mmol/L) | Cr (mmol/L) |
|---|---|---|---|---|---|
| Group A | 10 | ||||
| Pretreatment | 87.6 ± 40.9 | 48.3 ± 19.2 | 7.0 ± 1.4 | 64.3 ± 12.5 | |
| Day 3 after treatment | 77.9 ± 23.8 | 49.8 ± 13.2 | 7.6 ± 1.4 | 67.8 ± 10.3 | |
| Day 7 after treatment | 75.3 ± 22.7 | 50.7 ± 12.0 | 7.3 ± 1.1 | 59.7 ± 16.0 | |
| F | 0.458 | 0.064 | 0.488 | 0.952 | |
| P | 0.638 | 0.938 | 0.619 | 0.399 | |
| Group B | 10 | ||||
| Pretreatment | 90.7 ± 48.6 | 40.8 ± 20.0 | 7.3 ± 1.1 | 64.2 ± 12.6 | |
| Day 3 after treatment | 641.8 ± 212.5 | 745.3 ± 174.4 | 7.2 ± 0.8 | 65.8 ± 12.3 | |
| Day 7 after treatment | 84.0 ± 17.3 | 59.8 ± 11.4 | 7.4 ± 0.7 | 60.0 ± 18.4 | |
| F | 63.953 | 156.263 | 0.114 | 0.415 | |
| P | 0.000 | 0.000 | 0.893 | 0.665 | |
| Group C | 9 | ||||
| Pretreatment | 62.6 ± 22.3 | 39.9 ± 7.4 | 6.4 ± 1.2 | 65.0 ± 11.0 | |
| Day 3 after treatment | 643. 7 ± 164.7 | 762.4 ± 123.4 | 7.0 ± 1.2 | 64.7 ± 6.9 | |
| Day 7 after treatment | 75.6 ± 20.4 | 55.2 ± 10.8 | 6.9 ± 0.8 | 68.0 ± 12.8 | |
| F | 106.004 | 299.019 | 0.849 | 0.274 | |
| P | 0.000 | 0.000 | 0.44 | 0.763 | |
| Group D | 8 | ||||
| Pretreatment | 98.2 ± 16.3 | 41.8 ± 14.1 | 6.5 ± 1.1 | 58.8 ± 7.3 | |
| Day 3 after treatment | 573.5 ± 209.0 | 694.2 ± 184.4 | 6.8 ± 1.0 | 62.5 ± 8.6 | |
| Day 7 after treatment | 84.8 ± 6.8 | 51.9 ± 12.5 | 6.7 ± 0.9 | 63.5 ± 6.0 | |
| F | 42.270 | 97.609 | 0.104 | 0.920 | |
| P | 0.000 | 0.000 | 0.902 | 0.414 | |
Notes: ALT: compared among the four groups pretreatment (F = 1.763, P = 0.173); groups B, C, and D showed a significant difference from group A after treatment (F = 23.981, P = 0.000), with no difference between the three groups; ALT on day 3 was much higher than pretreatment and 7 days after treatment (P < 0.05) which returned to normal on day 7 (P0–7d = 0.41). AST: compared among the four groups pretreatment (F = 0.537, P = 0.660); groups B, C, and D showed a significant difference from group A after treatment (F = 58.518, P = 0.000), with no significant difference between the three groups; on day 3, the AST level was much higher than pretreatment and 7 days after treatment (P < 0.05) which returned to normal on day 7, P0–7d = 0.113. BUN: compared among the four groups pretreatment (F = 1.073, P = 0.374), no statistically significant difference between the four groups after treatment (F = 1.311, P = 0.287); on day 3, the BUN level was slightly higher than pretreatment (P0–3d = 0.030), which returned to normal on day 7, P0–7d = 0.236). Cr: compared among the four groups pretreatment (F = 0.553, P = 0.650); no statistically significant difference between the four groups after treatment (F = 0.236, P = 0.871); on day 3, the BUN level was slightly higher than pretreatment (P0–3d = 0.027), which return to normal on day 7, P0–7d = 0.894.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; Cr, blood creatinine.