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. 2013 Oct 10;8(10):e77097. doi: 10.1371/journal.pone.0077097

Figure 6. Schematic illustrating the metabolite changes induced by the reduction in IDHc expression.

Figure 6

The numbers 1 to 7 refers to points mentioned in the discussion. AlaAT, alanine aminotransferase; AspAT, aspartate aminotransferase; ACC, acetyl-CoA carboxylase; ACL, ATP-citrate lyase; ACOc, cytosolic isoform of aconitase; DHAP, dihydroxyacetone phosphate; FFA, free fatty acids; FUMc, cytosolic isoform of fumarase; GDH, glutamate dehydrogenase; Glnase, glutaminase; Glycerol-3-P, glycerol-3-phosphate; α-KG, alpha-ketoglutarate; IC, isocitrate; IDH1 (or IDHc), cytosolic isoform of NADP+-dependent isocitrate dehydrogenase; IDH2, mitochondrial isoform of NADP+-dependent isocitrate dehydrogenase; IDH3, mitochondrial isoform of NAD+-dependent isocitrate dehydrogenase; MDH1, cytosolic isoform of malate dehydrogenase; MDH2, mitochondrial isoform of malate dehydrogenase; MEc, cytosolic isoform of malic enzyme; NNT, nicotinamide nucleotide transhydrogenase; OAA, oxaloacetate; PC, pyruvate carboxylase; PDH, pyruvate dehydrogenase; Pyr, pyruvate.