Table 2. Summary of response profiles of functionally characterized lepidopteran PRs in Cluster I-IV.

Clusters	Receptor	Main ligand
Ⅰ	HvOR16	Z11-16:OH
	HvOR6	Z9-14:Ald
	HarmOR3	Z11-16:OH
	HassOR3	Z9-14:Ald
	AsegOR9	Z5-10:OAc
	AsegOR6	Z5-10:OH, Z5-10:OAc
	AsegOR1	Z5-10:OAc, Z7-12:OAc, Z8-12:OAc
	AsegOR7	Similar to AsegOR1, lower sensitivity
	AsegOR8	Similar to AsegOR6, lower sensitivity
	AsegOR10	Small response to Z9-14:OAc, Z5-10:OAc
Ⅱ	HvOR14	Z11-16:OAc
	MsOR1	Z11-16:OAc
	AsegOR5	Z9-14:OAc
Ⅲ	HvOR11	Ligand unknown
	HarmOR2	Broadly tuned
	HassOR2	Broadly tuned
	AsegOR3	Low sensitivity to all the tested compounds
Ⅳ	HvOR13	Z11-16:Ald
	HarmOR1	Z11-16:Ald
	HassOR1	Z11-16:Ald
	AtraOR3	Z11-16:Ald
	PxOR1	Z11-16:Ald
	AtraOR1	Z11,Z13-16:Ald
	ApolOR1	E6,Z11-16:Ald
	BmOR1	E10,Z12-16:OH
	AsegOR4	Z7-12:OAc