Table 3. Multivariate analysis to estimate the risk of ATV/r- over DRV/r-containing antiretroviral therapies for nephrolithiasis.
Model 1 crude (n=1,057) |
Model 2 adjusted (n=1,056) |
Model 3 adjusted (n=1,021) |
||||
---|---|---|---|---|---|---|
HR | 95%CI | HR | 95%CI | HR | 95%CI | |
ATV/r use over DRV/r | 27.05 | 3.687-198.5 | 27.08 | 3.680-199.3 | 21.47 | 2.879-160.2 |
Age per 1 year | 1.009 | 0.980-1.039 | 1.006 | 0.976-1.037 | ||
Male sex | 1.939 | 0.441-8.528 | 1.202 | 0.262-5.512 | ||
Weight per 1 kg increment | 0.988 | 0.956-1.021 | 0.979 | 0.947-1.012 | ||
Tenofovir use | 0.678 | 0.313-1.470 | ||||
Baseline serum uric acid per 1mg/dl increment | 1.418 | 1.150-1.750 | ||||
Past history of renal stone | 1.661 | 0.520-5.307 | ||||
Past exposure to IDV | 0.491 | 0.100-2.403 |
HR, Hazard ratio; CI, confidence interval; ATV/r, ritonavir-boosted atazanavir; DRV/r, ritonavir-boosted darunavir; HIV, IDV, indinavir.