Table 1.
Characteristics of the WHO pre-qualified OCVs
| Characteristics | Dukoral | Shanchol |
|---|---|---|
| WHO prequalification | Yes (October of 2001) | Yes (September of 2011) |
| Licensed ages | ≥ 2 years | ≥ 1 year |
| Number of doses for primary immunization | Age 2–5 years: three doses; age ≥ 6 years: two doses | Two doses |
| Interval between doses | ≥ 7 days (but < 6 weeks) | ≥ 14 days |
| Booster | Age 2–5 years: after 6 months; age ≥ 6 years: after 2 years | After 2 years |
| Administration | Oral with bicarbonate buffer (75 mL for ages 2–5 years; 150 mL for ages ≥ 6 years) | Oral |
| Food and water restrictions | No food or water 1 hour before and after vaccine ingestion | No restriction |
| Packaging | 3-mL single-dose vial and effervescent granules in sachet | 1.5-mL single-dose vial |
| Storage temperature | Storage at 2–8 °C | Storage at 2–8 °C |
| Packed volume per dose (centimeter3) | 136 | 17 |
| Price per dose (US dollars) | 4.75 | 1.85 |