Table 10.
Study | Country | Study type | Results | Disadvantage |
---|---|---|---|---|
Sakla and Lorson (2008) | USA | In vitro (cell-based) | Resveratrol elevated SMN2-luciferase expression by six fold and increased the exon 7-inclusion by 1.4 fold in a luciferase assay. These effects translated into only a one-fold increase in the full-length SMN2 transcript level. | Not reported |
Dayangac-Erden et al. (2009) | Turkey | In vitro (cell-based) | Resveratrol increased the full-length SMN2 mRNA and protein levels by 1.3-fold. | Not reported |