Table 1B.

Histone deacetylase (HDAC) inhibitors and their target enzymes.

Inhibitor	Target HDAC	IC50	Fold increase of full-length SMN2 transcript or SMN protein
VPA	HDAC1, HDAC2, HDAC3	0.7–20 mM	2–4
PBA	HDAC1, HDAC2	16 nM	0.4–2.4
M344	HDAC6	423 nM	3–7
LBH589	Pan HDACs	5–20 nM	10
SAHA	HDAC1, HDAC2, HDAC3, HDAC8, HDAC9	10 nM	5
TSA	HDAC5	1.8 nM	2
MS-275	HDAC1, HDAC2, HDAC3, HDAC9	0.5 μM	Unknown
Romidepsin	HDAC1 HDAC2	36 & 47 nM	5
Resveratrol	HDAC8	650 μM	1.3
Curcumin	HDAC8	25 μM	1.7
EGCG	Unknown	Unknown	1.4

EGCG – epigallocathecin gallate; M344 – benzamide 344; MS-275 – entinostat; PBA – phenylbutyrate; SAHA – suberoylanilidehydroxamic acid;TSA –trichostatin A;VPA – valproic acid.