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The primary sequences of IS6, IIS6, IIIS6, and IVS6 of CaV3.2 were aligned with S6 of NaVAb, NaVRh, KV1.2, and the CaV2.3 Domain II using the T-coffee algorithm. Underlined residues have been identified in previous studies as determinants of activation gating: Ile-217 in NaVAb, PVP locus in KV channels, and Ile-701 in CaV2.3. The underlined residues in CaV3.2 designate the IIS6 residues studied herein.
