Computer-based molecular models of Domains II and III (top center and bottom right panels) of CaV3.2 are shown in a schematic representation. Modeling of Domains II and III was based upon the atomic coordinates of NaVAb (PDB code 3RVY) (bottom panels) and NaVRh (PDB code 4DXW) (top panels). Top left and bottom left, Leu-908 (IIS4-S5) is shown in stick representation in blue and Ile-1013 (IIS6) and Asn-1548 (IIIS6) are shown in red. Top center panels, Leu-908 and Thr-911 (IIS4-S5) are shown in stick representation in blue and Ile-1013 (IIS6) and Asn-1548 (IIIS6) are shown in red. Right top and bottom panels, Val-907, Leu-908, and Thr-911 (IIS4-S5) are shown in stick representation in blue and Ile-1013 (IIS6) and Asn-1548 (IIIS6) are shown in red.