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. 2013 Aug 31;288(41):29403–29413. doi: 10.1074/jbc.M113.470708

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Subcellular localization of Cypher (A and B) and PKARII (C and D) in heart tissues of adult mice. A and B, Cypher localized at Z lines (arrows) in mouse cardiomyocytes as judged by α-actinin co-staining. Z line localization of Cypher was not perturbed by treatment of mice with isoproterenol; however, Cypher showed additionally slight intercalated disk localization (arrowheads) in treated hearts when compared with controls (compare inset in A and B). C and D, PKARII was found to localize at intercalated discs (arrowheads) in control hearts, as judged by plakoglobin counterstaining. Upon isoproterenol treatment, PKARII was found to localize in a more pronounced way to Z lines (arrows), in addition to its intercalated disk localization (compare inset in C and D). Sarcomeric α-actinin was used to mark Z-lines (arrows); plakoglobin was use to mark cardiac intercalated disks (arrowheads). Scale bars: 20 μm.