FIGURE 6.

The high femoral bone mass in DMP1–8kb-caPTHR1 mice depends on Wnt activation and is further increased by inhibiting bone resorption. Representative digital x-ray images of the hindlimb (A) and femoral BMD measured by DXA (B) in 6-week-old mice expressing the DMP1–8kb-caPTHR1 and/or the DMP1–8kb-Sost transgenes or alendronate, and WT littermates is shown; n = 9–12 mice per group. Bars represent the mean ± S.D. *, p < 0.05 versus respective controls not expressing the caPTHR1 transgene and lines connect conditions with p < 0.05, by two-way ANOVA.