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. 2013 Aug 20;288(41):29809–29820. doi: 10.1074/jbc.M113.485938

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Changes in volume and architecture in femoral cancellous bone of DMP1–8kb-caPTHR1 mice are blocked by Sost overexpression and enhanced by alendronate treatment. Representative micro-CT images (A) and the cancellous bone parameters bone volume (BV/TV), and trabecular thickness (Tb. Th.), separation (Tb. Sp.), and number (Tb. N.) (B) measured by micro-CT in the distal femur of 6-week-old mice expressing the DMP1–8kb-caPTHR1 and/or the DMP1–8kb-Sost transgenes or alendronate, and WT littermates. n = 4–5 mice per group. Bars represent the mean ± S.D. *, p < 0.05 versus respective controls not expressing the caPTHR1 transgene and lines connect conditions with p < 0.05, by two-way ANOVA.