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. 2013 Aug 23;288(41):29846–29861. doi: 10.1074/jbc.M113.500108

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — Selection of type 1 rPrP^Sc and further shift in conformational stability after PMCA of mixed type 1 + 2 sCJD with unglycosylated PrP^C substrate. A, conformational stability curve of type 1 rPrP^Sc obtained with europium-labeled mAb 12B2 before (red circles) and after 9 rounds of PMCA (purple hexagons). B, conformational stability curve of a typical pure type 2 rPrP^Sc obtained with europium-labeled mAb 3F4 before (blue squares) and after 9 rounds of PMCA (yellow diamonds).