Table 2.

SNPs showing suggestive GWAS significance (P<6.09×10⁶) in the meta-analysis for extraversion, neuroticism, and symptoms of anxiety, depression, and psychological distress. The number of cohorts included in each meta-analysis ranges between four (for anxiety) to eight (for personality).

	Ch	Position1	Effect Allele (EA)	Other Allele	EA Frequency Range	Gene/Closest gene (* denotes a SNP located in a gene)	Effect	Effect SE	P-value	Direction of Effect	P<0.05 for other traits (Effect size, P-value)
Personality Traits
Extraversion (E) N=6256
rs6782143	3	5768262	T	A	0.93–0.97	AC027119.1	0.251	0.052	1.19×10−6	++++++++	None
rs2470646	3	5775765	T	C	0.92–0.96	AC027119.1	0.211	0.045	2.91×10−6	++++++++	None
rs9598027	13	34297478	C	A	0.97–0.99	RP11-141M1.3	0.361	0.078	4.09×10−6	++++?-?+	None
rs4798680	18	8730726	A	G	0.39–0.47	KIAA0802*	0.086	0.019	5.39×10−6	++++++++	None
Neuroticism (N) N=6268
rs12067374	1	152568230	C	G	0.27–0.33	LCE3C (4kb)	0.114	0.024	2.72×10−6	+++++-++	None
rs7905170	10	79738238	G	A	0.18–0.20	POLR3A*	0.105	0.023	5.32×10−6	++++++++	D (0.06 ±0.03, P=0.02)
rs11634474	15	75116184	C	G	0.26–0.31	LMAN1L*	0.097	0.021	2.28×10−6	-+++++++	E (−0.04 ±0.02, P=0.04)
rs936229	15	75132319	A	G	0.23–0.26	ULK3*	0.110	0.022	9.97×10−7	-+++++++	None
rs3765066	15	75140854	G	A	0.29–0.37	SCAMP2*	0.096	0.020	8.93×10−7	-+++++++	E (−0.04 ±0.02, P=0.05)
rs1869959	15	75147332	A	C	0.25–0.32	SCAMP2*	0.099	0.020	1.18×10−6	-+++++++	E (−0.04 ±0.02, P=0.04)
rs11630918	15	75155896	C	T	0.39–0.54	SCAMP2*	0.095	0.019	4.22×10−7	-+++++++	None
Mood States
Anxiety (A) N=2840
rs1079196	3	59806778	A	G	0.19–0.21	FHIT*	0.179	0.033	8.00×10−8	+++	PD (0.08 ±0.03, P=0.01)
rs10428174	3	59814048	G	A	0.21–0.23	FHIT*	0.160	0.032	5.33×10−7	+++	PD (0.07 ±0.03, P=0.01)
rs2793109	10	31379846	A	T	0.48–0.53	ZNF438 (59kb)	0.132	0.027	1.47×10−6	+++	PD (0.07 ±0.02, P=4×10−3)
Depression (D) N=4525
rs7582472	2	134644794	C	T	0.17–0.19	MGAT5 (367kb) NCKAP5 (318kb)	0.132	0.028	1.59×10−6	+++++	PD (0.06 ±0.03, P=0.04)
rs2141848	4	92395356	A	C	0.44–0.46	FAM190A*	0.100	0.021	2.64×10−6	+++++	PD (0.09 ±0.03, P=6×10−4)
rs3808900	9	124992764	A	G	0.74–0.76	LHX6 (1,745bp)	0.115	0.025	2.89×10−6	+++++	PD (0.06 ±0.03, P=0.03); N (0.06 ±0.02, P=3×10−3); E (−0.04 ±0.02, P=0.04)
rs4888786	16	78394040	G	A	0.62–0.66	WWOX*	0.102	0.022	5.52×10−6	None
rs10410977	19	10443254	A	C	0.01–0.02	RAVER1*	0.693	0.139	6.75×10−7	+++++	PD (0.67 ±0.20, P=1×10−3)
Psychological Distress (PD) N=3310
rs10948347	6	47311898	T	C	0.93–0.96	TNFRSF21 (34kb)	0.269	0.058	4.01×10−6	++++	A (0.21 ±0.07, P=2×10−3)
rs9381534	6	47313491	G	A	0.95–0.97	TNFRSF21 (36kb)	0.297	0.064	2.88×10−6	++++	D (0.13 ±0.06, P=0.02); A (0.17 ±0.07, P=0.02)
rs4374821	6	47355493	G	A	0.94–0.90	TNFRSF21 (78kb)	0.259	0.053	1.07×10−6	++++	D (0.12 ±0.05, P=0.01); A (0.21 ±0.06, P=4×10−4)
rs7298903	12	117747210	T	C	0.86–0.91	NOS1*	0.185	0.041	5.39×10−6	++++	None

Ch: Chromosome

¹NCBI dbSNP Human Build 131 (GRCh37)

Note: Significant SNPs in strong linkage disequilibrium (r²>0.80 in HapMap phase 2/3 CEU sample or our own cohorts) with those in the table are not presented, they include: Extraversion: rs6782143 with rs17043388, rs1811510; rs2470646 with rs2470644, rs7621135, rs7618793, rs1452713; rs9598027 with rs2182058, rs9315242, rs9598025, rs9598026, rs9598029, rs9592004, rs10507414, rs7318085, rs7319180, rs17079650; Neuroticism: rs7905170 with rs4979936, rs4979937; rs11630918 with rs7497393, rs11072511, rs7495739, rs1127796, rs1130741, rs4886636, rs11072512, rs1133322, rs1133323, rs11856413, rs11072514, rs11072513; rs3765066 with rs11072518; rs936229 with rs1378938, rs7176022, rs7162232, rs9210, rs8031937, rs6495126, rs8042694, rs936230, rs6495127; Depression: rs7582472 with rs13429789; rs2141848 with rs7675583, rs10007512, rs6845679 Anxiety: rs10428174 with rs4679614, rs1872495, rs4679615; Psychological Distress: rs9381534 with rs9369675, rs6918220, rs9357529, rs3905310, rs9395248